Dimitry Sayenko, MD, PhD
Paula and Joseph C. "Rusty" Walter III Chair in Neuromodulation, Center for Neural Systems Restoration, Houston Methodist

Abstract

Neuromodulation of Spinal Sensorimotor Networks Using Invasive and Non-invasive Spinal Stimulation: “Determining the Right Fit”

Many individuals experience chronic sensorimotor impairments after spinal cord injury (SCI). As a result, they often seek novel or experimental therapeutic interventions as potential strategies for improving motor function. Activation of sub-functional longitudinal fibers across the lesion, and emerging responsiveness of spinal networks below the lesion to descending commands and proprioception is considered the main mechanism for both invasive and non-invasive spinal stimulation to restore function after paralysis. Despite advancements, comprehensive understanding of the most effective strategies for successful implementation of these techniques remains somewhat elusive. The purpose of this presentation is to articulate clinical and physiological perspectives on the use of transcutaneous (TSS) and epidural spinal stimulation (ESS) in combination with movement-specific training paradigms in individuals with chronic spinal cord injury (SCI) and in preclinical experimental animal models. 
 

Bio
Dr. Dimitry Sayenko graduated in 1996 from the Russian State Medical University with an MD degree. From 1996 to 2006, he was a researcher at the Institute for Biomedical Problems – the leading Russian research institute specializing in biomedical aspects of manned spaceflights. In 2005, he received a PhD in Aerospace Medicine, with a thesis on the effect of microgravity on postural control in cosmonauts and astronauts. Dr. Sayenko completed his postdoctoral training at the National Rehabilitation Center in Japan (2006-2008), as well as at the Toronto Rehabilitation Institute in Canada (2008-2012). From 2012 to 2014, Dr. Sayenko held a faculty appointment at the University of Louisville and the Frazier Rehab Institute, where he investigated the mechanisms of neuromodulation induced by epidural spinal stimulation. From 2014 to 2018, Dr. Sayenko worked at the UCLA, and utilized spinal stimulation in individuals with spinal cord injury to recover sensorimotor function in the upper and lower limbs. Dr. Sayenko’s current research at the Houston Methodist Research Institute focuses on the mechanisms and effects of spinal neuromodulation in the sensorimotor recovery after neurological disorders and injuries, including SCI and stroke.