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ROCHESTER, Minn. — Spinal cord stimulation and physical therapy have helped a man paralyzed since 2013 regain his ability to stand and walk with assistance. The results, achieved in a research collaboration between Mayo Clinic and UCLA, are reported in Nature … Continue reading

Here is today’s latest information in a brief article and video on the spinal cord injury trial testing Epi Stim Standing and Stepping in the ClinicalTrials.gov number, NCT02339233. Recovery of Over-Ground Walking after Chronic Motor Complete Spinal Cord Injury at the … Continue reading

The Canadian/American Spinal Research Organization (CSRO/ASRO) is a charitable organization (charitable registration # 11915 9515 RR0001) dedicated to the funding of targeted research to maximize functional recovery and cure paralysis caused by spinal cord injury. CSRO envisions a world without paralysis caused by spinal cord injury.

Working 2 Walk in Vancouver is now just a month away - so if you’ve been thinking about it, now's the time to register. As I've mentioned previously (Context, Strategy, Voice), there looks to be a combination of very provocative presentations and conversations lined up.

Good news on the legislative front in Ohio: we now have a Bill drafted and an author in the Ohio legislature. The Bill has not been introduced or been made public yet (and frankly, it needs a little tweaking), but its a great start.

The goal of the ‘SCI 2020: Launching a Decade for Disruption in Spinal Cord Injury Research’ conference is to initiate discussion across the SCI research community to launch a new decade of research that disrupts traditional barriers and brings about collaborative … Continue reading

There’s a great little story within the film, Shawshank Redemption. The main character, Andy Dufresne - who is serving time for a murder he didn’t commit - decides he’s going to try to open a prison library. He starts mailing letters to the state legislature to ask for books for the library. The key scene unfolds as follows ...

This year's Visionary Sponsor - and a long-time Working 2 Walk supporter - is the Craig H. Neilsen Foundation. We are extremely grateful for the Nielsen Foundation’s support for our Symposium and especially their support for our Travel Grant Scholarships.

There's still time to save on this year's Working 2 Walk Science & Advocacy Symposium - but only if you register by this Friday, September 7th.

EPFL (Ecole polytechnique fédérale de Lausanne) in Switzerland and UCLA (University of California in Los Angeles, California) have collaborated in making severed nerve fibers  regenerate across a complete SCI to form a bridge in rodents.  Their three part recipe for … Continue reading

When I first moved to Minneapolis from Philadelphia (which feels like a lifetime ago), I worked evenings in a hospital while still going to school during the day ...

I recently read a wonderful paper published in Nature addressing a stem cell experiment  for spinal cord injury.  This paper is very scientifically detailed, but they show the need for having the right age and origin of stem cell to … Continue reading

A non-invasive method to restore bladder function after a spinal cord injury continues to show progress in the Dr. Daniel Lu at UCLA.  This experiment showed positive results in 5 people eliminating the need for catheters for up to 4 … Continue reading

As part of our on-going effort to introduce you to our top-tier list of speakers this year, we're continuing to feature CureCast interviews with scientists and advocates who will present at Working 2 Walk this fall. Check out our latest conversation with Dr. Dennis Bourbeau.

The Working 2 Walk Science & Advocacy Symposium prides itself on putting the SCI Community at the center of the conversation about curative therapies. And it's one of the reasons our conference has one of the highest - if not the highest - numbers of attendees with a Spinal Cord Injury than other conferences of this kind.

One of the important strategies that labs have been focusing on for spinal cord injury has been how to best deal with CSPG (chondroitin sulfate proteoglycans) commonly known as the scar that builds up at the site of injury (lesion) … Continue reading

NervGen & Dr. Jerry Silver
NervGen & Dr. Jerry Silver

Please join us in congratulating Dr. Jerry Silver and Dr. Bradley Lang from Case Western Reserve University and the team at NervGen (https://www.nervgenpharma.com/) for the steps taken to bring a potential treatment forward for chronic Spinal Cord Injury, as well as other injuries
and disorders.

U2FP’s Scientific Advisory Board has assisted foundations who wish to fund promising and relevant research for the last several years. Thanks to Donna Sullivan’s leadership as our Special Projects Director, our Scientific Advisory Board reviewers, and the other key organizations that U2FP has collaborated with in the funding of Dr. Silver’s work:

• The Hong Kong SCI Fund
• SCISucks
• The United Paralysis Foundation.

As difficult as it is for the scientific enterprise to find discoveries such as this, it may
be equally difficult to navigate the obstacles and challenges inherent to bringing
those discoveries to a relevant treatment for SCI. So, we will continue to keep you
abreast of that progress and continue to look for ways that our community can help.

W2W Agenda is Up | CureCast Interview with Dr. Andrei Krossioukov
W2W Agenda is Up | CureCast Interview with Dr. Andrei Krossioukov

This year’s Working 2 Walk Science & Advocacy Symposium continues to take shape. We’ve just posted the first iteration of our Agenda so you can see what’s happening and when. Please know that we’ll continue to update the Agenda in the coming weeks as the presentation titles are finalized.

And as part of our on-going effort to introduce you to our top-tier list of speakers this year, we’re continuing to feature CureCast interviews with scientists and advocates who will present at Working 2 Walk this fall. Check out our latest conversation with Dr. Andrei Krossioukov, who talks about the potential that spinal stimulation holds for autonomic funtions for chronic spinal cord injury: bowel, bladder, seal function, blood pressure regulation. Check it out — then drop your thoughts to us at curecast@u2fp.org

The Rick Hansen Institute is a Vancouver-based not-for-profit organization that drives innovation in spinal cord injury research and care. Learn More

Our publicity efforts, web traffic, and social media conversations will increase steadily in the next couple of months; be a part of the buzz as an official Working 2 Walk Sponsor. Join the Rick Hansen Institute and our other valued sponsors of this year's Symposium. Sponsor the Symposium

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Even though we may be years away from a robust stem cell treatment coming to the market for spinal cord injury, the lab work continues to progress and show great promise.  What we don’t know is; which stem cell will … Continue reading

For those following SCI research in the electrical stimulation field, this open access article in Nature Communications is worth a read.  Here, the Gregoire Courtine lab describes the concept and project where brain-controlled modulation coupled with constant stimulation during gait … Continue reading

The annual Working 2 Walk symposium is now open for registrations.  Mark your calendars for October 19th & 20th, 2018 in Vancouver, Canada.  Claim your spot at this LINK.  The list of speakers you’ll hear are at this LINK.     … Continue reading

See the Full Article LINK at Neuroscience Research Australia: Researchers from Neuroscience Research Australia (NeuRA), The University of Sydney, and HammondCare have found surviving sensory nerve connections in areas of no sensation in 50% of people living with complete thoracic … Continue reading

Working 2 Walk Teaser: Dr. Karim Fouad on pericytes, controlled inflammation & how to improve translation
Working 2 Walk Teaser: Dr. Karim Fouad on pericytes, controlled inflammation & how to improve translation

Dear Ryan,

Our team is hard at work on a dynamic and exciting agenda for Working 2 Walk in Vancouver, Canada this year - much of which I will be keeping you current on via these newsletters, so stay tuned. Believe it or not the Working 2 Walk Symposium (October 19-20) is less than three months away!

And don't worry - we are planning to launch online registration for Working 2 Walk this Friday, July 27th, so keep an eye out for another newsletter announcement then.

One of the new things we are doing is featuring interviews on the podcast with some of the scientists and advocates who will be speaking at the Symposium. We thought this might be a good opportunity for you to familiarize yourself with those individuals and hear a little bit about their work ahead of this year's conference.

Please check out this great conversational interview Kate and Matthew had with Dr. Karim Fouad.
Dr. Fouad about how he ended up in this field and the more recent research that he has been involved with: the discovery of pericytes and their role in inhibiting blood flow after injury and what might be done about that; the potential for inciting a controlled inflammatory response to open a window for recovery after injury; and Karim's ideas for improving the translation of science to clinical relevance. Check it out - then drop your thoughts to us at curecast@u2fp.org

And if you haven't listened to it before, check out our interview from a couple months ago with Dr. David Magnuson who will also be presenting at Working 2 Walk in Vancouver this October.

Kate and Matthew have a great conversation with Dr. Magnuson about his research interests - which range from fashioning miniature wheelchairs for rodents to testing the effects of shallow water walking. His work poses some provocative questions for rehab science and functional restoration. Have a listen, and then drop us a note (curecast@u2fp.org) with your feedback.

Special thanks to the Rick Hansen Institute, this year's Title Sponsor! This is the first time Working 2 Walk has been held outside the United States, and we see it as the next chapter in our ever-expanding mission to unite the SCI Community around the world.

As always, don't forget to Fuel The Journey. We've got a lot of ground to cover, and we can't do it without you!

Join us!

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Read the Full Article at eLife Sciences The vagus nerve reports on the state of many of the organs in our body, including the heart, the lungs and the gut, and it relays this information to various neural control networks … Continue reading

Read the Full Article at eLife Sciences The vagus nerve reports on the state of many of the organs in our body, including the heart, the lungs and the gut, and it relays this information to various neural control networks … Continue reading

Read this Full Story at Science Digest HERE Most people with spinal cord injury are paralyzed from the injury site down, even when the cord isn’t completely severed. Why don’t the spared portions of the spinal cord keep working? Researchers … Continue reading

Read this Full Story at Science Digest HERE Most people with spinal cord injury are paralyzed from the injury site down, even when the cord isn’t completely severed. Why don’t the spared portions of the spinal cord keep working? Researchers … Continue reading

Read the Full Article at Globe Newswire.   VANCOUVER, British Columbia, July 18, 2018 (GLOBE NEWSWIRE) — NervGen Pharma Corp. (“NervGen”), in Vancouver, and Case Western Reserve University (“Case Western Reserve”) in Cleveland have entered into an exclusive worldwide licensing agreement to research, develop and … Continue reading

NeuroRecovery Technologies specializes in Spinal Cord Stimulation for spinal cord injury. Nick Terrafranca, CEO, describes the technology and an update on the progress of their research.

The molecule inhibits adult axon regeneration, but appears to stimulate young neurons by Scott LaFee Recovery after severe spinal cord injury is notoriously fraught, with permanent paralysis often the result. In recent years, researchers have increasingly turned to stem cell-based … Continue reading

Do We Need a Hero
Do We Need a Hero

I’ve been thinking a lot lately about what we’re doing here at U2FP (as well I should). Some of you might not believe it, but I listen just about as much as I talk...at least in this work. I listen a lot to researchers, other foundations and non-profits, my colleagues, clinicians, state legislators and other invested stakeholders. But most of all, I listen to you; meaning those of you who live with Spinal Cord Injuries, and your loved ones. After all, I'm one of those loved ones too.

There are so many varied layers and complexities to this work. And what keeps me focused is what I know from my own experience as a father to a son with a SCI, and what I hear from so many of you. This is a large part of why I am always writing to you about becoming a part of what we do.

Our partners in the sciences and across the larger research and advocacy landscape need us to become more involved; and not just from the bleachers. I’ve told you before that I love movies for the power they have to move us and tell our story about what it means to be human. But they also have great power to influence habits of thought that lie in the shallows of our subconscious.

For instance, almost all action movies rely on a singular, gotta-fix-it-myself-guy (almost always a dude). And he usually fixes things with a gun. It's a hero myth. In other words, in order to fix our problems whatever they are we need a singular sacrificial hero. But what kind of message does that send back out into the real world? I can tell you its not a message that works for solving problems. Especially the problem of paralysis.

Problems are solved by a team, a community, a movement of people. That means US. So resist any thoughts you may have or messaging you may hear (especially if it comes from me) that puts any hero up on pedestal. Because what we need are pedestals big enough for all of US to get us to Cures.

If you're not sure what you can do beyond:

educating yourself about the science
calling legislators in our various state initiatives
wheeling or running in a Team U2FP race
getting to know SCI Researchers near you - or if you are a researcher, getting to know the SCI community members near you
becoming a monthly donor

Please reach out to us at unite@u2fp.org and we'll chat about whatever ideas you have. We'd love to hear from you. We are going to spend a bit more time at this year's Working 2 Walk talking about some strategic advocacy opportunities, so your ideas will be very valuable to the conversation.

Join us,

Most studies on microtubules in the nervous system have focused on the dynamic properties of the microtubules, with stabilization by taxol and related drugs being proposed as a therapeutic for nerve injury. However, while initial indications were hopeful, more recent … Continue reading

Most studies on microtubules in the nervous system have focused on the dynamic properties of the microtubules, with stabilization by taxol and related drugs being proposed as a therapeutic for nerve injury. However, while initial indications were hopeful, more recent … Continue reading

Working 2 Walk - Dr. Magnuson Teaser
Working 2 Walk - Dr. Magnuson Teaser

Working 2 Walk 2018 continues to take shape.

One of the speakers at this year’s Symposium will be Dr. David Magnuson - Friends for Michael Endowed Professor, Departments of Neurological Surgery, Anatomical Sciences & Neurobiology, and Biomedical Engineering at the University of Louisville in Kentucky. To get a flavor for his research and focus, check out the podcast conversation Kate Willette and I had with David a few months back.

We will be posting information on this year's Working 2 Walk Speakers over the next few months. This is meant to prepare you for more fruitful interactions and engagement at the Symposium. Please send your questions and/or comments to curecast@u2fp.org. We’d love to hear from you and your feedback will help guide some of the conversations we are planning for Working 2 Walk.

Check out the Working 2 Walk home page here. Thanks to our Title Sponsor the Rick Hansen Institute and our other valued sponsors: The Craig H. Nielsen Foundation , Global Technologies, The Canadian Spinal Research Organization, Kennedy Krieger Institute, The Christopher and Dana Reeve Foundation, DP Clinical and Push To Walk.

Sponsor the Symposium

There's still time! If your organization is interested in becoming a sponsor for this year’s conference please send an email to matthewrodreick@u2fp.org. Get these updates sent right to your inbox — sign up here!

Dr. Aharon Lev-Tov, Chair of Medical Neurobiology, discusses his department, research into spinal cord injury, and Canadian collaborations.

T. George Hornby
Rehabilitation Institute of Chicago
Department of Physical Therapy
University of Illinois at Chicago

Click Here to watch the video over on Christal's Medium page.

Authors: Herrity AN1,2, Williams CS3, Angeli CA1,4, Harkema SJ1,2,4, Hubscher CH5,6 Deficits in urologic function after spinal cord injury (SCI) manifest both as a failure to store and empty, greatly impacting daily life. While current management strategies are necessary for … Continue reading

Read about the objective to investigate the efficacy of spinal cord epidural stimulation (scES) as a promising therapy to improve bladder control after SCI.

Researchers at King’s have shown that rats with spinal cord injuries can re-learn skilled hand movements after being treated with a gene therapy that could be switched on and off using a common antibiotic. Researchers at King’s College London and … Continue reading

Scientists say they have taken a significant step towards the goal of giving paralysed people control of their hands again.

Jan-Eric Ahlfors, CEO and CSO of Fortuna, presented at the Fourth International Vatican Conference “Unite to Cure”.

Marquette University professor Murray Blackmore was awarded a $1.6 million grant from the National Institutes of Health to continue his research of spinal cord injury and paralysis.

Great news from the filmmakers of the Cure Map documentary & and progress on the front-lines of our fight for research funding through the Pennsylvania Legislature.

See all the great ways we're building capacity with our Cure Advocacy Network initiative.

Dr. Ida Fox talks “Improving Upper Extremity Function in Cervical SCI” in her Working 2 Walk video from last October; while Dr. David Magnuson discusses Matthew & Kate on U2FP's CureCast podcast.

We were saddened to learn of the recent passing of Dr. Jean de Vellis, a founding member of our Scientific Advisory Board (SAB). More than 5 years ago, Dr. de Vellis helped U2FP assemble a review board of scientists that would help smaller foundations vet their funding decisions.

Two worlds come together in this personal reflection about what it will take to cure paralysis.

We’ve just released Megan Moynahan’s video from this past year’s Working 2 Walk in Miami. We also have a new podcast interview up with the creators of the documentary film, The Cure Map. Check it out!